논문 및 발표

PCNA Regulation and Repair Pathway Choice: From Biochemistry to AI-driven Discovery

E Ryu

2026 KSBMB International Conference — "From Molecules to Megabytes: AI and Big Data Transforming Life Science"

BEXCO, Busan, Korea · 2026.05.27–29

Deciphering AlphaFold-predicted Protein-Protein Interactions in Replication-associated Pathways

E Ryu

2026 한국분자·세포생물학회(KSMCB) 세포주기분과 하계 심포지엄

Sol Beach Yangyang, Gangwon, Korea · 2026.06.25–26

Proteome-wide in silico screening for human protein-protein interactions

JCW Ernst W. Schmid, Helen Zhu, Eunjin Ryu, Yang Lim, Agata Smogorzewska, et al.

bioRxiv

ATAD5 functions as a regulatory platform for Ub–PCNA deubiquitination

E Ryu, J Yoo, MS Kang, NY Ha, Y Jang, J Kim, Y Kim, BG Kim, S Kim, et al.

Proceedings of the National Academy of Sciences, 121(34), e2315759121

ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair

Y Kim, NY Ha, MS Kang, E Ryu, G Yi, J Yoo, N Kang, BG Kim, K Myung, et al.

Nature Communications, 15(1), 10496

Expanding the genetic and phenotypic landscape of replication factor C complex-related disorders: RFC4 deficiency is linked to a multisystemic disorder

M Morimoto, E Ryu, BJ Steger, A Dixit, Y Saito, J Yoo, AT van der Ven, et al.

The American Journal of Human Genetics, 111(9), 1970-1993

Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination

SH Park, N Kim, N Kang, E Ryu, EA Lee, JS Ra, A Gartner, S Kang, et al.

Nucleic Acids Research, 51(19), 10519-10535

Active DNA damage eviction by HLTF stimulates nucleotide excision repair

M van Toorn, Y Turkyilmaz, S Han, D Zhou, HS Kim, I Salas-Armenteros, et al.

Molecular Cell, 82(7), 1343-1358

Distinct motifs in ATAD5 C-terminal domain modulate PCNA unloading process

E Ryu, NY Ha, W Jung, J Yoo, K Myung, S Kang

Cells, 11(11), 1832

ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork

S Kim, N Kang, SH Park, J Wells, T Hwang, E Ryu, B Kim, S Hwang, et al.

Nucleic Acids Research, 48(13), 7218-7238

Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

SG Espanola, H Song, E Ryu, A Saxena, ES Kim, JE Manegold, et al.

Nature Cell Biology, 22(12), 1411-1422

Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes

MS Kang, E Ryu, SW Lee, J Park, NY Ha, JS Ra, YJ Kim, J Kim, et al.

Nature Communications, 10(1), 2420

PCNA unloading is negatively regulated by BET proteins

MS Kang, J Kim, E Ryu, NY Ha, S Hwang, BG Kim, JS Ra, YJ Kim, et al.

Cell Reports, 29(13), 4632-4645

Single Molecule Measurements Reveal Conformational Transitions During DNA Clamp Loading and Unloading

SW Lee, E Ryu, S Kang, H Kim

Biophysical Journal, 116(3), 40a

Eukaryotic DNA replication: Orchestrated action of multi-subunit protein complexes

S Kang, MS Kang, E Ryu, K Myung

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 809, 58-69